Mendrick usually adopts a holistically progressive approach, encouraging and promoting the adoption of cutting-edge technologies and innovative methodologies. She values proactive collaboration between different regulatory entities and emphasizes the significance of research aligning with regulatory functions.

Donna Mendrick exemplifies a multi-disciplinary approach towards regulatory compliance and safety. She's vested in the integration of advanced technologies like artificial intelligence and in vitro models to enhance the efficiency and effectiveness of regulatory processes. Moreover, she demonstrates a keen interest in optimizing risk assessments and reducing dependencies on animal testing. Her observations are often aligned with promoting advancements in regulatory science through integration and collaborations with both internal and external entities.