Casale's approach to inspection is meticulous and stringent, with a strong focus on sterile processes, staff compliance, and environmental conditions. He values a clean, well-organized setting and substantiated procedures, and tends to prioritize potential cross-contamination issues.

FDA auditor Matthew B Casale shows a keen interest in sterile production areas and hygiene protocols. He consistently flags violations related to improperly sanitized facilities and unprofessional hygiene practices by personnel. Casale is meticulous and has a keen eye for process integrity, especially about the handling of sterile products, equipment, and related supplies. His focus suggests a high concern over potential cross-contamination and strict adherence to FDA contamination prevention standards.